It will become freaky now, folks. Apart from using an EEG to record brain activity in order to control a BCI, one can, in principle, record electrical activity directly from nerve cells, using implantable electrodes as sensors to target individual cells. This approach has certain advantages (more) and some rather obvious problems, which have to do with the necessity of an implantation.
First experiments with microelectrodes in the brain were performed as early as in the 1960s, but only in recent years microelectrodes became sophisticated enough to produce a stable interface with the brain without moving or causing scar tissue to grow (more).
As far as BCIs are concerned, by now, using a systems with implantable electrodes, monkeys have managed to move cursors on a screen and even operate a robot arm via the internet. In some individual cases, severely handicapped humans with locked-in-syndrome (more) have also received electrode-based systems, generally with encouraging results.

eeg / why is it a language / further nerve cell chatter
firing neurons / implantation / where the future lies
further chatter > neurons


Not actually a medical expression. The term is used for very severe forms of a variety of neurological diseases that lead to the phenomenon of a totally self-conscious patient being absolutely unable to interact with the world around.

The most famous locked-in-syndrome in literature is shown by the old man in Stevenson's "Treasure Island". Full-scale locked-ins are extremely rare, but severe ALS or a pure brainstem stroke can indeed lead to a nearly total paralysis. Because of their unaltered intellectual capabilities, locked-in-patients are the "ideal" candidates for real-time-BCIs.

Locked-in syndromes

Some background science here: Learn about eeg in medicine and why it can de used for BCI-control.